INSIGHTS INTO ENDOTHELIN-3 AND MULTIPLE SCLEROSIS

Insights into Endothelin-3 and Multiple Sclerosis

Endothelins are powerful vasoconstrictor peptides that play numerous other roles.Endothelin-1 (ET1) is the principal isoform produced by the endothelium in the human cardiovascular system.Endothelin-3 (ET3) and its rPptor affinity have been demonstrated to support neuronal repair mechanisms throughout life.In multiple sclerosis (MS), the role of va

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Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients.

BACKGROUND: Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs.Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicular trafficking, exocytosis and secreti

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Distributionally robust optimization for virtual power plant clusters considering carbon emission-based dynamic dispatch priority

A virtual power plant (VPP) is an effective way to manage distributed energy resources.Virtual power plant cluster (VPPC) is constructed due to the increasing number of VPPs.It has great potential in carbon emission reduction through coordination between VPPs.Therefore, GASTRO-ASSIST a dynamic dispatch priority model is proposed.The model adjusts t

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Comparison of Reef Fish Survey Data Gathered by Open and Closed Circuit SCUBA Divers Reveals Differences in Areas With Higher Fishing Pressure.

Visual survey by divers using open-circuit (OC) SCUBA is the most widely used approach to survey coral reef fishes.Therefore, it is important to quantify sources of bias in OC surveys, such as the possibility that avoidance of OC divers by fishes can lead to undercounting in areas where targeted species have come to associate divers with a risk of

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